Elevated MCV (mean corpuscular volume) means your red blood cells are larger than normal. This typically indicates macrocytic anemia, often caused by vitamin B12 or folate deficiency.
MCV measures the average size of your red blood cells. Normal ranges are 80-100 femtoliters (fl). Values above 100 fl suggest macrocytosis. Your doctor uses this measurement alongside other blood tests to diagnose conditions.
The most common causes of elevated MCV fall into three categories:
Many people confuse elevated MCV with elevated MCH (mean corpuscular hemoglobin). While both indicate abnormal red blood cells, MCV measures cell size while MCH measures hemoglobin content. A high MCV doesn't always mean high MCH.
Doctors diagnose elevated MCV through a complete blood count (CBC) test. Treatment depends on the underlying cause. For vitamin deficiencies, supplements are often prescribed. For liver disease, addressing the root cause is essential.
In my experience working with patients, those with elevated MCV often report fatigue and weakness. Addressing the underlying cause can improve energy levels and health.